Fenlegm Solubilizer CAS 23828-92-4 Ambroksiol Hidroklorür toz olmayan Numune

• CAS No.: 23828-92-4
• Formula: C13h19br2cln2o
• EINECS: 245-899-2
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Industrial
• Hayır. Modeli.: Lingding23828-92-4
• Colour: White
• mw: 414.56
• Taşıma Paketi: Based on Customer′s Needs
• Teknik Özelikler: 1kg
• Ticari Marka: Lingding
• Menşei: Hebei, China
• Üretim Kapasitesi: 9000 Kilogram/Kilograms Per Month

Ürün Açıklaması

Product Description   

Ambroxol Hydrochloride is an active metabolite of expectorant bromohexine (n-demethylated, cyclohexyl parapposite to introduce trans hydroxyl), with lower toxicity than bromohexine, but higher activity than bromohexine. Ambroxol hydrochloride is a mucolytic agent developed by Boehringer Ingelheim in Germany. It was first marketed in Germany in the early 1980s, and then in France, Italy, Japan, Spain and many other countries. As a new generation mucolytic agent, ambroxol can improve sputum excretion, and has the effect of promoting lung surface active substances, airway secretion and ciliary movement. Clinically, it can regulate the secretion of mucus and mucous pulp, activate the wiggle of cilia, easily dilute sputum, enhance the outward transport of mucus Chemicalbook, and facilitate the discharge. It can also promote the synthesis of lung surfactant, so as to maintain alveolar tension and ensure lung function indicators. Promote the penetration of antibiotics into tissues to increase the concentration and enhance the bactericidal effect; Antioxidant, reduce the release of inflammatory mediators to reduce the inflammatory response; In order to improve the efficacy of antispasmolytic drugs, it can cooperate with bronchial antispasmolytic substances. Therefore, this drug can be widely used in clinical for acute and chronic respiratory diseases accompanied by abnormal secretion of respiratory tract, especially for expectorant treatment of chronic bronchitis, neonatal respiratory distress and auxiliary treatment of lung surgery. It has the advantages of low toxicity, exact efficacy, and can produce good synergistic effect with antibiotics, and is one of the most commonly used expectorant drugs.

 

Indication:
Ambroxol hydrochloride is a cough suppressant and expectorant for the treatment of acute and chronic respiratory diseases, especially chronic bronchitis.
Pharmacological effect:
1. Relieving cough and reducing phlegm
Ambroxol hydrochloride mainly acts on respiratory secretory cells, regulating the secretion of mucous and serous substances, increasing serous secretion, cracking the polysaccharide fiber of acid glycoprotein in sputum, inhibiting the synthesis of acid protein in mucus glands and goblets, reducing the viscosity of sputum, making sputum thin and easy to be discharged; At the same time, the drug can also increase the frequency and intensity of cilia movement of respiratory tract, promote sputum discharge and self-purification of respiratory Chemicalbook tract.
2. Antioxidant effect
Ambroxol hydrochloride has obvious antioxidant effect and plays an important role in the lung disease of reactive free oxygen groups. Studies have shown that ambroxol has a strong inhibitory effect on H2O-2 produced by neutrophils. In addition, ambroxol activates the intracellular glutathione system and promotes the synthesis of intracellular glutathione (GSH) to combat the destructive effects of oxygen free radicals.
Clinical application:
1. The application of ambroxol hydrochloride in the respiratory system can increase the secretion of serous fluid in the airway, dilute the sputum and discharge it easily, thus improving the respiratory condition and making PS in the respiratory mucosa play a normal protective role; At the same time, it also has a high affinity for the lungs, which can promote the synthesis and secretion of PS in the lungs, so as to maintain the stability of the alveoli, which is conducive to the improvement of the function of the alveoli. Therefore, the early application of ambroxol hydrochloride can relieve respiratory obstruction, improve ventilation, shorten the course of disease, reduce various complications, and is often used in the treatment of chronic bronchitis aggravation, asthmatic bronchitis, pneumonia, lung abscess and other diseases.
2. Use in age-related COPD (chronic obstructive pulmonary disease) COPD is a common respiratory disease. With the increase of age, airway ciliary clearance function of the elderly is gradually declining, and lung antioxidant effect is decreased. Ambroxol has anti-inflammatory, antioxidant and increase ciliary movement, and can improve airway epithelial surface clearance function, so as to prevent COPD.
3. Clinical Application in neonatal respiratory system Neonatal respiratory distress syndrome (NRDS) is caused by deficiency of pulmonary surfactant (PS). Ambroxol can promote the synthesis and secretion of endogenous PS Chemicalbook, increase the release of endogenous PS by alveolar type II cells, thus reducing the surface tension of alveoli, reaerating the atrophy of alveoli, thereby improving lung function, shortening the time of mechanical ventilation and oxygen therapy, and reducing the risk factors of bronchophenia.
4. Lung protection after cardiopulmonary Bypass (CPB) is the most common complication after cardiothoracic surgery. Foreign studies have confirmed that after ischemia reperfusion injury of the lung after CPB, neutrophils and platelets are activated, aggregate in the lung, attach to the capillary wall of the lung, release a large number of oxygen free radicals, inflammatory mediators, damage alveolar type II cells and vascular endothelial cells, resulting in reduced PS synthesis and release. In addition, alveolar - capillary membrane permeability increases, alveolar fluid accumulation, PS consumption is excessive, can not play a normal physiological effect, so that alveolar surface tension increases, alveolar tends to collapse, resulting in respiratory disorders. Ambroxol hydrochloride can effectively promote the synthesis and secretion of PS after thoracic surgery, inhibit activated neutrophil response, reduce respiratory resistance and airway hyperreactivity, affect airway wall ion transport and potential difference, and reduce lung injury after cardiopulmonary bypass.
 
Matters needing attention:
1. Contraindicated:
*Allergic to ambroxol hydrochloride.
*The first three months of pregnancy.
2. Caution:
*Patients with malignant cilia syndrome.
*Liver and kidney insufficiency.
*Patients with gastric ulcer.
*Glaucoma.
*Women in the third trimester of pregnancy or feeding Chemicalbook milk.
3. The synergic treatment of this product with antibiotics can increase the concentration of antibiotics in lung tissue.
4. Occasional mild gastrointestinal adverse reactions, symptoms disappeared after dose reduction.

Product Name:	Coluracetam
CAS:	135463-81-9
MF:	C19H23N3O3
MW:	341.4
Melting point:	/ºC
Mol File:	135463-81-9.mol

  

 

Packaging & Shipping

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg  Fast: 3-7 days    Door to door service,    easy to pick up the goods	Suitable for more than 50kg       Fast: 3-7 days       High cost       Port to port,        professional broker needed	Suitable for more than 500kg     Slow: 7-45 days     Low cost     Port to port,      professional broker needed

Company Profile

 

Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.