Temel bilgiler.
Application
Internal Medicine
Product Name
Propranolol Hydrochloride Tablets
Pharmaceutical Technology
Chemical Synthesis
Ürün Açıklaması
Product Description
Product name: Propranolol Hydrochloride Tablets
Character:This product is white.
Indications:
1. As a secondary prevention, reduce the mortality of myocardial infarction.
2. Hypertension (alone or in combination with other antihypertensive drugs).
3. Labour-type angina pectoris.
4. Control supraventricular tachyarrhythmia and ventricular arrhythmia, especially those related to catecholamine or caused by digitalis. It can be used to control the ventricular rate of atrial flutter and atrial fibrillation with poor effect of digitalis, and can also be used for intractable premature contraction to improve the symptoms of patients.
5. Reduce the outflow tract pressure difference of hypertrophic cardiomyopathy, and relieve symptoms such as angina pectoris, palpitation and syncope.
6. Cooperation α Receptor blockers are used to control tachycardia in patients with pheochromocytoma.
7. It can be used to control the heart rate of hyperthyroidism and also to treat thyroid crisis.
Adverse reactions:
The application of this product can cause adverse reactions of the central nervous system such as dizziness, blurred consciousness (especially in the elderly), mental depression, slow response, etc; Dizziness (caused by hypotension); Heart rate is too slow (<50 times/minute); The rare ones are bronchospasm, dyspnea and congestive heart failure; Fever and pharyngalgia (agranulocytosis), rash (allergic reaction), bleeding tendency (thrombocytopenia) are more rare; When adverse reactions persist, special attention should be paid to cold limbs, diarrhea, fatigue, dry eyes, mouth or skin, nausea, numbness of fingers and toes, abnormal fatigue, etc.
Taboo:
1. Bronchial asthma.
2. Cardiogenic shock.
3. Cardiac block (2-3 degree atrioventricular block).
4. Severe or acute heart failure.
5. Sinus bradycardia.
Overdose:
In general, if the drug is excessive, the stomach contents should be emptied as soon as possible to prevent inhalation pneumonia. Atropine should be given when bradycardia occurs, and isoproterenol should be used with caution; Install a pacemaker if necessary. Lidocaine or phenytoin sodium were given to ventricular premature beats. Take digitalis or diuretics when heart failure occurs. When blood pressure is low, give vasopressor drugs, such as norepinephrine or epinephrine. For bronchial asthma, epinephrine or aminophylline should be given. This drug cannot be discharged by dialysis.
Pharmacology and toxicology:
1. Pharmacological action
(1) Propranolol is a non-selective competitive inhibitor of epinephrine β Receptor blockers. Block cardiac β 1, β 2 receptor, which antagonizes the sympathetic nerve excitation and catecholamine action, reduces the contractility and contraction speed of the heart, inhibits the contraction of vascular smooth muscle, reduces the myocardial oxygen consumption, and restores the balance of oxygen supply and demand of ischemic myocardium at a low level, which can be used to treat angina pectoris.
(2) The adrenergic stimulation that inhibits the cardiac pacemaker potential is used to treat arrhythmia. This product can also be used to treat hypertension by blocking central and adrenergic neurons, inhibiting renin release and reducing cardiac output.
(3) Competitive antagonism of isoproterenol and norepinephrine, blocking β 2 receptor, reducing plasma renin activity. May cause bronchospasm. Inhibit insulin secretion, raise blood sugar, mask hypoglycemia symptoms, and delay the recovery of hypoglycemia.
(4) It has obvious antiplatelet aggregation effect, which is mainly related to the membrane stability of the drug and the inhibition of platelet membrane Ca2+transport.
2. Carcinogenesis, mutagenicity and reproductive toxicity
Within 18 months, rats or mice were administered 150 mg/kg daily for 18 months, without obvious toxic reaction and drug-related carcinogenic effect. No damage of reproductive ability related to the effect of propranolol was found in the reproductive experiment. When given to animals 10 times the dose for human use, it shows that this product has embryotoxicity.
Storage:
Closed storage.
Detailed Photos
Company Profile
ARTHA GROUP
The manufacturer and developer of high quality medicine and APIs that benefit human health.
OUR VERSION
ARTHA group is the manufacturer and developer of high quality medicine and APIs that benefit human health, we are committed to supplying quality products for using in the pharmaceutical, healthcare and veterinary industries.
OUR MISSION
ARTHA group is to create more value for our clients, to provide a comprehensive range of customized value-added services and products and to meet each client's specific requirements.
OUR PRODUCTSDrug Impurity |
Tablets |
Suppositories |
Solution(Lotion) |
Infusion |
Capsule |
API |
Producting&Packing
Adres:
Yuexiu District, Guangzhou, Guangdong, China
İşletme Türü:
Üretici/Fabrika
İşletme Aralığı:
Kimyasallar, Sağlık ve Tıp
Yönetim Sistemi Sertifikasyonu:
ISO 9001, GMP
Şirket Tanıtımı:
AT, ilaç endüstrisinde 20 yılı aşkın küresel iş deneyimi ile Ar-Ge, üretim ve ticareti entegre eden bir grup şirketidir. API′den hazırlıklara kadar entegre bir üretim ve ticaret tedarik zincirine sahibiz ve yabancı madde son teknoloji ürünü biyoteknoloji ürünleri üretme ve geliştirme yeteneğine sahibiz; Hindistan′da bir üretim ve satış ağımız var ve Çin ve Hindistan tıp arasında 20 yıldan uzun süredir karşılıklı gelişim için bir bağlantı kurmaya kararlıyız.
Ürünlerimiz şunları içerir:
1. Formülasyon ürünleri:
(1) infüzyonlar: Kayıt devam ediyor ve tamamlandı,
2′den fazla ülke ve bölge deniz aşırı (10) enjeksiyon: Ürünler 10′den fazla ülkeye ve bölgeye gönderilir
(3) Tabletler, kapsüller: Kalitemizi ve fiyat avantajımızı garanti etmek için Hint ham maddelerinin çok düşük fiyatı
2.API ve Orta Seviye: Süper düşük fiyat, kalite güvencesi, Hindistan′dan doğrudan satın alma ve teslimat
3.yabancı madde: Guangzhou ve Zhengzhou′daki iki laboratuvar 40′den fazla AR-GE personeliyle sektörde önde gelen AR-GE avantajlarına sahiptir
4.Biyolojik ürünler: Tüy Büyüme tavsiye edici; NMN
5.Kağıt yapımı kimyasal